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Department of Anesthesiology and Perioperative Medicine Heersink School of Medicine

Department of Anesthesiology and Perioperative Medicine

REINVENT

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The Research Integration Venture (REINVENT) program is a collaborative research seed funding program for faculty projects within the Department of Anesthesiology and Perioperative Medicine.

The goal of REINVENT is to promote innovative research, encourage the integration of our clinical, basic, and translational research faculty, foster mentorship, and allocate resources (both time and money) transparently and competitively, with an eye toward future project sustainability. As a merit seed funding program, it encourages both intra-departmental and inter-departmental collaborations and team building, availability of academic time and financial support.

Collaboration is encouraged between clinical and basic/translational faculty; projects can focus on any aspect of research including clinical, education, quality, and operations.

If you have questions about abstracts, contact Brant Wagener at bwagener@uabmc.edu. If you have questions about redcap or your submission, contact Brittany Massie at bmassie@uabmc.edu. The next REINVENT cycle due date is Friday, October 3rd, 2025. 

Awardees 

  • Spring 2025

    1. "Vasorin: Role in cardiac dysfunction during pregnancy induced hypertension". Saravanakumar Murugesan, PhD (PI), Teshi Kaushik, MD (Co-PI), Tamas Jilling, MD (Co-I)

    2. "The Pathological Role of Mitochondria in the Progression of Preeclampsia (PE) Affects Both the Mother and the Fetus During and After Birth." Praveen K Dubey, M. Sc. Ph.D. (PI), Dan E. Berkowitz M.D. (Co-PI), Kaushik, Teshi, M.D. (Co-PI), Annalese Neuenschwander, M.D. (Co-PI)

    3. "Evaluation of Low Molecular Weight Hyaluronic Acid as a Novel Biomarker for Diagnosis of Pulmonary Aspiration in Children". Sadis Matalon, MSc, PhD, ScD (h.c.) (PI), Ammar Saadoon Alishlash, MD (Co-PI)

    4. "AI Predictions of Difficult Airways: Confirming remarkable predictive power on CT Scans." Matt Sherrer, MD (PI), Ryan C. Godwin, MS, PhD (Co-PI), Sandeep Bodduluri, PhD (Co-PI), Ryan L. Melvin, MA, PhD (Co-PI).

  • Spring 2024

    Justin Routman, M.D., MSHA (PI), Ben Tuck, M.D. (Co-I), Jared Bobulski, MD (Co-I)
    Comparison of Remimazolam with Propofol for Procedural Sedation in TEE

  • Spring 2023

    Aftab Ahmad, Ph.D., (PI), David W. Miller, M.D., (Co-PI), John C. Briggs, M.D., (Co-I)
    Circulating Factors and Multiorgan Dysfunction in ARDS

    Andre F. Gosling, M.D., (PI), Ryan C. Godwin, M.S., Ph.D., (Co-PI), Ryan L. Melvin, M.A., Ph.D., (Co-PI)
    Measurement of Pulse Arrival and Transit Times to Approximate Arterial Stiffness in Cardiac Surgery Patients

    Weifeng Song, M.D., Ph.D., (PI), Ryan L. Melvin, M.A., Ph.D., (Co-PI), Ryan C. Godwin, M.S., Ph.D., (Co-I)
    Continous Assessment of Cerebral Autoregulation After Subarachnoid Hemmorrhade in Neuro ICU: A Feasibility Study 

  • Summer 2022

    Tekuila Carter, M.D. (PI), Lee Ann Riesenberg, Ph.D., M.S., R.N. (Co-I)
    Tools for Direct Observation and Assessment of Anesthesiology Resident Procedure Skills: A Systematic Review

    Jennifer DeBerry, Ph.D. (PI), Promil Kukreja, M.D., Ph.D. (Co-I), Rakesh Patel, Ph.D. (Co-I), Ryan Melvin, Ph.D. (Co-I), Ryan Godwin, Ph.D. (Co-I)
    Effects of sustained-release oral sodium nitrite supplementation on pain-related outcomes and peri- and postoperative physiology in people undergoing unilateral all-component revision total knee arthroplasty

    Michelle D Tubinis, M.D. (PI), Hanna Hussey, M.D. (Co-PI), Tamas Jilling, M.D. (Co-PI), Saravanakumar Murugesan, Ph.D. (Co-I)
    Angiotensinogen/Vasorin Ratio in Peripheral Blood (PLASMA) as Biomarker of Preeclampsia

  • Spring 2021

    Ahmed Lazrak, Dr.Sc.
    Epithelial ion channels expression and function regulation in pulmonary aspiration

    Riaz Karukappdath, M.D.
    Mitochondrial dysfunction contributes to sepsis induced cardiac dysfunction

  • Rapid REINVENT

    Due to the COVID-19 pandemic, our regular Spring REINVENT cycle was deferred and the Rapid REINVENT program was implemented in April. The purpose of the program was to promote and encourage innovation in COVID-19 research. Seven projects received funding in the first cycle in April and five projects received funding in May.

    April Cycle 

    Kevin S. Harrod, Ph.D. (PI), Brant Wagener, M.D., Ph.D. (Co-I), Jessy Deshane, Ph.D. (Co-I)
    Modeling of COVID-19 and SARS-CoV-2 in human lung epithelium.

    Qiang Ding, Ph.D., Kevin S. Harrod, Ph.D., Brant Wagener, M.D., Ph.D., Jean-Francois Pittet, M.D.
    Repurposing already-available drugs to treat COVID-19; a pilot study for the effect of already-available drugs on COVID-19 virus entry and replication in lung epithelial and endothelial cells

    Jean-Francois Pittet, M.D., DEAA and Jaroslaw W. Zmijewski, Ph.D.
    Therapeutic recovery of immunosuppression and metabolic maladaptation induced by COVID-19 infection

    Dylan R. Addis, M.D.
    Investigation of VEGF and sFlt-1 levels in the pathogenesis and severity of COVID-19 disease

    Zhen Zheng, M.D. M.S.
    Penehyclidine protects lung from SARS-CoV-2-induced endothelial barrier disruption via limiting MLC2 phosphorylation - A novel intervention to ARDS in COVID-19

    Brant Wagener, M.D. Ph.D., Timothy J. Ness, M.D. Ph.D., Sonya Heath, M.D., Sadis Matalon, Ph.D., D.Sc.
    Exploratory study of the effect of tranexamic acid treatment on the progression of COVID-19 in Outpatients

    Sadis Matalon, PhD, D.Sc. (PI), Ahmed Lazrak, D. Sc., (Co-PI)
    Inhibition of Lung Ion Channel Activities by SARS CoV-2 S (spike) Protein

    May Cycle

    PI: Shama Ahmad, Ph.D., Co-PI: Aftab Ahmad, Ph.D.
    Protease activated receptor (PAR) dependent cardiomyocyte damage due to SARS-CoV2 Spike protein

    Co-PIs: Jean-Francois Pittet, M.D., Marisa Marques, M.D., Jori May, M.D. and Nita Limdi, Ph.D.
    Insights into COVID-19-Mediated Activation of the Coagulation Cascade

    PI: Saurabh Aggarwal, M.D., Ph.D.
    The role of SARS-CoV-2 Spike Protein in Impairing Bactericidal Function of Macrophages: Therapeutic Potential of Raltegravir

    PI: Jianguo Gu, M.B., Ph.D.; Co-PI: Sadis Matalon, Ph.D., Dr.Sc. (Hon.), FAPS
    Neurogenic lung inflammation and its therapeutic implications in COVID-19

    PI: Promil Kukreja, M.D.,Ph.D., Co-I: Hari Kalagara, M.D., Peter Nagi, M.D., Jeff Dobyns, M.D., MSHA
    Effects of COVID pandemic on care and outcomes of elderly hip fracture patients.

  • Fall Cycle 2020

    Andrew Barker, M.D.
    The Effect of Guanfacine on Delirium in Elderly Critically Ill Patients 

    Mark Powell, M.D.
    Exosome cargo from preeclamptic patients mediates endothelial dysfuntion, subsequent cardiovascular remodeling, and the preeclamptic pehnotype

    Alethia Selliers, M.D.
    Precision Medicine in Anesthesia: Genetic Component in Opioid-induced Respiratory Depression

Contact

Brant Wagener, M.D., Ph.D.

Brant Wagener, M.D., Ph.D.
Resident researchers are available through the RMRET program. Please contact Dr. Wagener for questions. 

 

 

 

Ayesha Bryant, M.D., MSPHAyesha Bryant, M.D., MSPH
IRB and regulatory assistance is available via Dr. Bryant. Applicants are encouraged to meet with Dr. Bryant prior to submitting their proposal to discuss the timeline required to obtain the necessary regulatory approval.