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New research presented by University of Alabama at Birmingham researchers shows that a 2.4mg dose of the obesity drug semaglutide can reduce the risk of Type 2 diabetes, or T2D, by 60 percent.
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In groundbreaking diabetes research over the past two decades, Anath Shalev, M.D., has shown that the protein TXNIP regulates survival and function of beta cells, the pancreatic cells that produce the hormone insulin to lower levels of glucose in the blood. Downregulation or inhibition of TXNIP in beta cells protects against diabetes in mouse models, and a repurposed clinical drug that inhibits TXNIP shows promising results in people with recent-onset Type 1 diabetes.
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Alabama, a state with many counties in the United States Diabetes Belt, saw an increase in new-onset Type 2 diabetes among youth during the COVID-19 pandemic. Results published in the Journal of Clinical Endocrinology & Metabolism showed the significant increase and indicated that Medicaid enrollees and males were disproportionately affected by the disease.
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Carbohydrates are directly linked to the development of Type 2 diabetes, but a higher-carb diet is underused in research models.
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A study from the University of Alabama at Birmingham is looking into a drug-free approach to treat type 2 diabetes. The research focuses on using diet changes to target the fat around organs like the pancreas and liver.
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W. Timothy Garvey, M.D., was named University Professor in the School of Health Professions Department of Nutrition Sciences. Garvey joined UAB in 2003 as chair of the Department of Nutrition Sciences, where he served until 2018.
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A novel therapy developed at the University of Alabama at Birmingham ameliorates obesity and Type 2 diabetes in mice fed a high-fat diet. The therapy acts through sustained release of nitric oxide, a gaseous signaling chemical whose most important function in the body is relaxing the inner muscles of blood vessels.
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According to the Centers for Disease Control and Prevention, more than 37 million Americans have diabetes, and approximately 90-95 percent of them have Type 2 diabetes. Individuals with Type 2 diabetes are at an increased risk of poor cardiovascular outcomes, leading to an estimated $37.3 billion a year in heart disease-associated care.
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Maintaining a healthy diet is important for your body’s overall health, reducing risk from many chronic noncommunicable diseases, such as diabetes, heart disease and cancer.
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In a recent study published in Circulation: Genomic and Precision Medicine, University of Alabama at Birmingham researchers found that, while many African Americans, especially those with a higher African ancestry proportion, have a favorable lipid profile, they are at a higher risk of developing diabetes than those of white/European ancestry. A favorable lipid profile indicates there are fewer components of body fat that can lead to cardiovascular and metabolic disease. Researchers believe this may be driven by genetic factors associated with geographic ancestry.