Mentor: Dr. Jia Xu, Department of Genetics
Postdoc Position in Cancer Biology or Epigenetics focused on Breast Cancer Brain Metastasis
The position entails:
- Working with a high degree of independence; participating in projects within the laboratory.
- Performing and troubleshooting experiments related to cancer biology, biochemistry, cell, and molecular biology.
- Collecting, summarizing, analyzing, and professionally interpreting data.
- Developing experiment modifications where needed.
- Using advanced knowledge and experience of lab practices to support, direct and teach others.
- Perform other duties as assigned.
The Xu Lab employs a multidisciplinary approach, including RNA-seq, Single-Cell sequencing, Proteolysis targeting chimeric (PROTAC) technology, biochemistry, and in vivo mouse models, to interrogate the molecular mechanism of epigenetic regulation in breast cancer brain metastasis. Our disease focus is solid tumors, with an emphasis on breast and prostate cancer. The detailed research information and lab personnel can be found on our Lab website: https://www.thexulab.org.
We are seeking a Postdoctoral Fellow to dissect the molecular mechanism of abnormal expression of epigenetic factors regulating breast cancer brain metastasis. Meanwhile, the postdoc fellow will have an excellent opportunity to develop novel therapeutic strategies to target these epigenetic factors with newly invented technologies, such as PROTAC.
Doctorates in cancer biology, epigenetics, molecular biology, and cellular biology-related fields are more than welcome. More specifically, the research involves (i) Cancer Cell signaling research and CRISPR screening genes involved in therapy resistance (ii) in vitro and in vivo testing of therapeutic compounds. It requires knowledge of basic biochemistry and molecular biology lab techniques, DNA/RNA extraction as well as (q)PCR/RT-(q)PCR, DNA cloning (ligation, transformation), DNA gel electrophoresis, Western blot (important), cell culturing experiments, transfection/transduction, Immunoprecipitation (IP), Virus infection, colony formation assay, mouse work experience (optional) and cell imaging.
Annual Salary Range: $56,000 - $70,000, depending on the research experience and publication record.
Excellent wet lab skills and experience with molecular and cell biology methods and protocols (including transfection) are essential. Candidates must have extensive experience with (q)PCR, primer design, DNA cloning (ligation, transformation), plasmid preps, DNA/RNA extraction in preparation for sequencing, gel electrophoresis (agarose, polyacrylamide), and cell culturing with bacterial and mammalian cells. Familiarity with RNA-seq, antibiotic resistance/sensitivity testing, drug dilutions, bacterial isolation, and/or quantification via plate reader and imaging instruments would be highly advantageous. The candidate must be dedicated, self-driven, self-motivated, collegiate, and be able to communicate well with scientists from diverse backgrounds.
To apply, please contact the faculty mentor, Dr. Jia Xu, at
About our Postdoc Office
UAB is committed to the development and success of outstanding postdoctoral scientists. Here at UAB, nearly 300 postdoctoral fellows are training currently in a variety of disciplines. Competitive postdoc awards are available including internships, grant incentives, funds to enhance education and collaboration outside UAB, and teaching opportunities at local universities. There is also a Postdoc Research Day with monetary awards. The Office of Postdoctoral Education strongly encourages UAB research mentors to follow the National Research Service Award stipend level guidelines, and postdoctoral scholars qualify for health, life, and other insurances. They also have the right to participate in the university’s 403(b) program and enjoy vacation, sick leave, maternity/paternity leave, and other benefits.
About the University
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