The UAB Department of Microbiology welcomed Hongjin Zheng, Ph.D., as associate professor in June 2025.
Zheng earned his undergraduate degree in biology from the University of Science and Technology of China, followed by a Ph.D. in biochemistry from the University of Washington in Seattle, where he focused on the structure and function of biomolecules.
As a structural biologist specializing in cryo-electron microscopy, Zheng’s research centers on uncovering the structure-function relationships of disease-related membrane proteins, particularly membrane transporters critical for substrate translocation. He completed his postdoctoral training at the Janelia Research Campus of the Howard Hughes Medical Institute before joining the University of Colorado Anschutz Medical Campus as an assistant professor. He led a research program there for 10 years, producing significant structural insights into human solute carriers and bacterial ABC transporters.
Zheng shares his passion for structural biology and excitement in his new role.
What is your primary area of expertise, and what sparked your passion for it?
Zheng: My primary area of expertise is the structural biology of membrane transport, focusing on using cryo-electron microscopy to elucidate the mechanisms of related proteins. We know how subtle changes in transporter structure could disrupt essential processes, leading to severe health conditions. The scarcity of targeted therapies for these transporters inspired me to explore how structural insights could drive the development of novel treatments.
What inspired you to pursue a career in this field?
Zheng: My pursuit of structural biology is inspired by a deep curiosity about the molecular mechanisms that govern protein function. I am fascinated by how proteins, particularly membrane transporters, orchestrate critical biological processes and how their dysfunction contributes to diseases. A detailed structural visualization of these molecules is a vital step.
What aspects of your new role here are you most excited about?
Zheng: I am thrilled to join UAB’s vibrant structural biology community, which is known for its cutting-edge research and collaborative environment. I am particularly excited to contribute my expertise in cryo-electron microscopy and membrane transporter research to advance our understanding of critical biological processes. The opportunity to collaborate with UAB’s talented researchers, leverage state-of-the-art facilities like the cryo-EM core, and mentor the next generation of scientists is incredibly motivating. I look forward to integrating my work with UAB’s mission to drive biomedical innovation, particularly in addressing disease mechanisms through structural insights.
What are your goals for making an impact through both your teaching and patient care in this role?
Zheng: My goal is to make a meaningful impact at UAB by advancing both scientific discovery and education. I aim to inspire and mentor the next generation of scientists by integrating my expertise into engaging classroom and laboratory experiences. By guiding students in hands-on research and coursework, I aim to spark their curiosity and equip them with the skills to tackle critical questions in structural biology, particularly regarding membrane proteins, such as transporters.