Jake Chen

Professor
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142 THT
(205) 996-0738

Research and Teaching Interests: Big data analytics, translational bioinformatics, systems biology, personalized medicine

Dr. Jake Y. Chen is the Triton Endowed Professor of Biomedical Informatics and Data Science at the UAB School of Medicine, with joint appointments in Genetics, Computer Science, and Biomedical Engineering, and is the founding director of the Systems Pharmacology AI Research Center (SPARC) and AI.MED lab. Over 25 years, he has advanced AI-driven biomedical informatics, network/systems biology, and computational drug discovery by developing systems pharmacology models, multi-omics AI frameworks, and digital twin simulations that integrate clinical, genomic, and real-world data for precision medicine. He has 250+ peer-reviewed publications and 300+ invited talks worldwide.

Dr. Chen also leads and convenes large, multi-institutional collaborations and contributes to national biomedical AI strategy and translational informatics infrastructure. He serves as the Contact MPI for CONNECT, an NIH U54-funded national AI-infrastructure initiative (2024–present) focused on building AI-ready biomedical knowledge networks and has advised NIH and the U.S. Congress (via NIDDK panels) while collaborating with FDA efforts related to AI-driven biomedical innovation. A recognized leader in AI-driven systems pharmacology, he is a Fellow of ACMI, AIMBE, and AMIA, an ACM Distinguished Member, and has received honors including the “Top 100 AI Leaders in Drug Discovery and Healthcare” (Deep Knowledge Analytics, 2019) and the CAST-USA Pioneer Award (2023).