Department of Neurobiology
School of Medicine
University of Alabama at Birmingham
Lucas Pozzo-Miller, PhD
Associate Professor
Current Lab Members
Michelle Amaral, PhD
Gaston Calfa, PhD
Chris Chapleau, PhD
Yong Li, PhD
Contact Information:
Lab Phone: 205-934-6359
Office Phone: 205-975-4659
Fax: 205-934-6571
Past
Lab Members
Dr. Antonio Campos-Torres (
Dr. Pablo Pomata (Facultad de Medicina, University of Buenos
Aires, Argentina)
Dr. Mariana Alonso (Pasteur Institute, Paris, France)
Dr. Mary Eve McCutchen
Dr. William J Tyler (Assistant Professor, School of Life Sciences,
Arizona State University, Tucson, AZ)
My long-term research interest is to
characterize the functional role of structurally defined neuronal compartments
such as spines, dendrites, and presynaptic terminals, and how they participate
in synaptic function and plasticity. The work in the lab focuses on the transient
elevations of intracellular free Ca2+ concentration induced by neuronal
activity, and defining their role in synaptic plasticity. The lab
investigates the effects of neurotrophins on synapses as an initial
approach to characterize the regulation of synaptic transmission and
plasticity by slow-acting, non-classical neuromodulators.
Lucas' Curriculum
Vitae
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From Pozzo Miller, Petrozzino, Golarai &
Connor, Journal of Neurophysiology 76: 554-562 (1996).
The large dendritic
arbors of central neurons allow for massive parallel synaptic input
as well as input-specific signal processing. Identifying the sources
and spatio-temporal patterns of intracellular calcium transients is
important to understand the role of different neuronal compartments
in synaptic integration. Optical imaging of fluorescent indicators sensitive
to free calcium ion is specially suited to study such phenomena by
simultaneous, non-invasive access to large regions of the dendritic
tree in individual central neurons.
Lucas' Bibliography
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From Petrozzino, Pozzo Miller & Connor,
Neuron 14: 1223-1231 (1995).
Last updated July
2008
You can reach Lucas by
e-mail at: lucaspm@uab.edu
or by more conventional
cable methods at:
phone: 205-975-4659
fax: 205-934-6571
or by snail-mail at:
Department of Neurobiology,
SHEL-1002
University of Alabama
at Birmingham
1825 University Blvd.
Birmingham, AL
35294-2182
Click on Frank's mustache
to go back to the
Department
of Neurobiology Web Page
Our daily struggle...
"...to distinguish
evidence from propaganda,
probability from
certainty,
rational beliefs
from superstitions,
data from assertions,
science from folklore,
theory from dogma,
and opportunity
from crisis."
PD Hurd
"I don't care whether I'm remembered...
As a matter of fact, there's a lot of people who would like to forget about
me as soon as possible, and I'm on their side!
You know? Just . . . hurry up and get it over with.
I do what I do because I like doing it, I do it for my amusement first,
if it amuses you . . . that's fine.
I'm happy that you'll participate in it. But, uh, after I am dead and gone,
there is no need to deal with any of this stuff, because it is not written
for future generations, it is not performed for future generations.
It is performed for now.
Get it while it's hot, you know?
That's it"
Frank Zappa
Copyright 1996-2008 by Lucas Pozzo-Miller